The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology
نویسندگان
چکیده
منابع مشابه
Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.
In this issue of Clinical Cancer Research , Koyanagi et al. (1) present results that indicate that microphthalmic-associated transcription factor (Mitf) levels as measured in circulating tumor cells correlate to stage of disease and thereby further support the notion that this transcription factor is proproliferative. Of particular interest is that the rate of detection of Mitf in circulating t...
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The microphthalmia transcription factor MITF plays a pivotal role in the development and differentiation of melanocytes. The purpose of this work was to investigate the expression and function of the melanocyte-specific isoform MITF-M in human melanoma. We found that MITF-M is repressed in 8 of 14 established melanoma cell lines tested. Transfection of MITF-M into a melanoma cell line (518A2) l...
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BACKGROUND Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient efficacy. Thus, identification of new melanocyte/melanoma antigens that serve as potential novel candidate biomarkers in melanoma is an important area for investigation. METHO...
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15 صفحه اولThe microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
The microphthalmia transcription factor (Mitf) activates melanocyte-specific gene expression, is critical for survival and proliferation of melanocytes during development, and has been described as an oncogene in malignant melanoma. SWI/SNF complexes are ATP-dependent chromatin-remodeling enzymes that play a role in many developmental processes. To determine the requirement for SWI/SNF enzymes ...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2017
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2017.9